I have

GREP Find – command + option + F
GREP Change – command + option + control + F
GREP Change/Find – option + control + F

This way I only have to lift my pointer finger or my ring finger as I'm searching through the document. Also, the Find/Change dialog box isn't blocking my view.

@rhadin

I frequently use Butler (https://manytricks.com/butler/) and my NuLOOQ to automate repetitive tasks. Butler lets you program a series of keystrokes, (for example: command + down / command + shift + down / delete), and then lets you to give this set of keystrokes a keyboard shortcut.
I set one of my programmable NuLOOQ buttons to type that shortcut, so all I have to do is hit one button whenever, for example, I want to delete the paragraph following the one my cursor is on.
My question is, can I do the same thing with X-Keys? NuLOOQ only has 5 programmable buttons. I would love to have 16 or 24 or more.

Thanks.