It depends on how many pages you have only if you have 80 or so pages, and of course the thickness of the paper.
Depending, you can get 80 pages to fold saddle stitch, I am of the thinking that you shouldn't adjust for creep manually. That is a job for the prepress, but that's another debate. When I was doing impositions I would calculate the creep for the sheet into the imposition.
Neither here nor there when you go over 80 odd pages.
When you get to over 80 pages, for example, your book will be perfect bound.
Meaning it will be do in 4, 8, 16's or 32's, which are then folded and stacked on each page. So for example, Page 1 – 32, is imposed and printed, then 33 – 64, and so on, each section is stacked on top of the other.
There really isn't any creep going on here.
What you are now concerned with is how much the glue is going to be used on each section to glue them together. It usually extends out to about 5 mm.
For example: If the Outside margins are 10mm then you should make the inside margins about 17mm.
This will compensate for the page being glued, and it will account for the bend in the page, so the page looks centered when opened.
But in saying all that – there are many different ideas, and many different ways to calculate this. Are the prepress going to account for the glue in the spine in the imposition?
Your best bet is to contact your printers and ask them what margins you should use, you could even get them to send you out a dummy book (a blank book that is finished and folded and glued) so that you can see how it looks. you can then take the book and remove the sections and measure with a rule.
If in you're in any way unsure you should consult your printer.